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2019•Antimicrobial Agents and ChemotherapyOpen access

In Vitro Activity of Bedaquiline and Delamanid against Nontuberculous Mycobacteria, Including Macrolide-Resistant Clinical Isolates

Dae Hun Kim, Byung Woo Jhun, Seong Mi Moon, Su‐Young Kim, Kyeongman Jeon, O Jung Kwon, Hee Jae Huh, Nam Yong Lee, Sung Jae Shin, Charles L. Daley, Won‐Jung Koh

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Abstract

We evaluated the in vitro activities of the antimicrobial drugs bedaquiline and delamanid against the major pathogenic nontuberculous mycobacteria (NTM). Delamanid showed high MIC values for all NTM except Mycobacterium kansasii . However, bedaquiline showed low MIC values for the major pathogenic NTM, including Mycobacterium avium complex, Mycobacterium abscessus subsp. abscessus , M. abscessus subsp. massiliense , and M. kansasii .

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What this paper is about

We evaluated the in vitro activities of the antimicrobial drugs bedaquiline and delamanid against the major pathogenic nontuberculous mycobacteria (NTM). Delamanid showed high MIC values for all NTM except Mycobacterium kansasii . However, bedaquiline showed low MIC values for the major pathogenic NTM, including Mycobacterium avium complex, Mycobacterium abscessus subsp. abscessus , M. abscessus subsp. massiliense , and M. kansasii .

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Available abstract

We evaluated the in vitro activities of the antimicrobial drugs bedaquiline and delamanid against the major pathogenic nontuberculous mycobacteria (NTM). Delamanid showed high MIC values for all NTM except Mycobacterium kansasii . However, bedaquiline showed low MIC values for the major pathogenic NTM, including Mycobacterium avium complex, Mycobacterium abscessus subsp. abscessus , M. abscessus subsp. massiliense , and M. kansasii .

Key concepts: Bedaquiline, Nontuberculous mycobacteria, Microbiology, In vitro, Macrolide Antibiotics, Antibiotics, Biology, Mycobacterium

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