2019•EBioMedicineOpen access

Future perspectives of Sleeping Beauty transposon system in cancer research

Xiu Chen, Di Xu, Jian Zhang, Jinhai Tang

Abstract

With the unsolved challenges to explore potential predictors of metastasis in colorectal cancer patients, Nicoloso and colleagues endeavored in this issue to combine a transposon-based forward genetic screen with the forced Single Cell Suspension assay (fSCS) to discover specific regulators of metastatic colorectal cancer [1]. They found that the fSCS was a simple and scalable in vitro assay to select cells with pro-metastatic traits. Meanwhile, the Sleeping Beauty transposon integration was proven to generate fSCS-resistant colorectal cancer cells.

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Key concepts: Colorectal cancer, Metastasis, Medicine, Cancer, Sleeping Beauty transposon system, Oncology, Internal medicine, Bioinformatics