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2019•Antimicrobial Agents and ChemotherapyOpen access

In VitroSynergy andIn VivoActivity of Tigecycline-Ciprofloxacin Combination Therapy against Vibrio vulnificus Sepsis

Seong Eun Kim, Hee Kyung Kim, Su‐Mi Choi, Yohan Yu, Uh Jin Kim, Kalifa Sanneh Darboe, Seung‐Ji Kang, Kyung‐Hwa Park, Gaeun Kang, Young Ran Kim, Joon Haeng Rhee, Sook‐In Jung, Hee‐Chang Jang

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Abstract

The mortality rate associated with Vibrio vulnificus sepsis remains high. Anin vitrotime-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, combination treatment with tigecycline-ciprofloxacin may be an effective novel antibiotic regimen for V. vulnificus sepsis.

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What this paper is about

The mortality rate associated with Vibrio vulnificus sepsis remains high. Anin vitrotime-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, combination treatment with tigecycline-ciprofloxacin may be an effective novel antibiotic regimen for V. vulnificus sepsis.

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OpenAlex reports 9 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The mortality rate associated with Vibrio vulnificus sepsis remains high. Anin vitrotime-kill assay revealed synergism between tigecycline and ciprofloxacin. The survival rate was significantly higher in mice treated with tigecycline plus ciprofloxacin than in mice treated with cefotaxime plus minocycline. Thus, combination treatment with tigecycline-ciprofloxacin may be an effective novel antibiotic regimen for V. vulnificus sepsis.

Key concepts: Vibrio vulnificus, Tigecycline, Ciprofloxacin, Minocycline, Sepsis, Microbiology, Antibiotics, Medicine

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In VitroSynergy andIn VivoActivity of Tigecycline-Ciprofloxacin Combination Therapy against Vibrio vulnificus Sepsis — Research Paper | ScholarLens