Transplacental transfer of organochlorine pesticides: Concentration ratio and chiral properties

Currently, there is limited information about the mechanism of the human transplacental transfer for organochlorine pesticides (OCPs). This study aimed to evaluate the transplacental transfer of OCPs to better understand the influencing factors of exposure and transplacental efficiency. The study involved quantitative determination of OCPs and the enantiomer fraction (EF) of chiral OCPs in pregnant women from Wuhan, China. The results indicate that the exposure levels of OCPs varied in the order: maternal serum > cord serum > placenta. Chiral contaminants, such as α-HCH, o,p′-DDD and o,p′-DDT, were non-racemic in the three biological matrices, wherein EFα-HCH < 0.5, EFo,p′-DDD < 0.5, EFo,p′-DDT > 0.5. For HCHs, the concentration ratio between cord serum and maternal serum (Rcm) <1, while for DDXs, the Rcm ≈ 1, indicating that the transport efficiency of different pollutants is related to the physicochemical properties. These results showed that placenta seems to be a more efficient barrier for β-HCH than for p,p′-DDE. The concentration ratios across placenta significantly lower than 1 and the enantiomeric selective transfer imply that some OCPs may have more complicated maternal-fetus transfer mechanisms, involving both simple diffusion and active transport. To the best of our knowledge, this is the first study to investigate the transfer of OCPs and their enantiomer fractions across placenta. These findings could expand the database of chemical exposure in biological matrices and improve the understanding of the mechanisms of transplacental transfer of OCPs.