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2018•Leiden Repository (Leiden University)Open access

On the pathogenesis and clinical outcome of ANCA-associated vasculitis

Chinar Rahmattulla

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Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated\n vasculitis (AAV), including granulomatosis with polyangiitis (Wegener’s)\n (GPA) and microscopic polyangiitis (MPA), is a small-to-medium vessel\n vasculitis that affect multiple organs and is life-threatening when\n untreated. In this thesis, several aspects of ANCA-associated vasculitis\n concerning genetics, clinical and histopathological classification, treatment\n and long-term outcome were investigated.

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Antineutrophil cytoplasmic antibody (ANCA)-associated\n vasculitis (AAV), including granulomatosis with polyangiitis (Wegener’s)\n (GPA) and microscopic polyangiitis (MPA), is a small-to-medium vessel\n vasculitis that affect multiple organs and is life-threatening when\n untreated. In this thesis, several aspects of ANCA-associated vasculitis\n concerning genetics, clinical and histopathological classification, treatment\n and long-term outcome were investigated.

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Available abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated\n vasculitis (AAV), including granulomatosis with polyangiitis (Wegener’s)\n (GPA) and microscopic polyangiitis (MPA), is a small-to-medium vessel\n vasculitis that affect multiple organs and is life-threatening when\n untreated. In this thesis, several aspects of ANCA-associated vasculitis\n concerning genetics, clinical and histopathological classification, treatment\n and long-term outcome were investigated.

Key concepts: Microscopic polyangiitis, Vasculitis, Granulomatosis with polyangiitis, ANCA-Associated Vasculitis, Anti-neutrophil cytoplasmic antibody, Medicine, Pathogenesis, Pathology

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