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2019•Anticancer ResearchOpen access

In Vitro Anticancer Activities of B6 Vitamers: A Mini-review

Taisuke Matsuo, Yasuyuki Sadzuka

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Abstract

Vitamin B6 compounds, including pyridoxine, pyridoxal, pyridoxamine, and their phosphorylated forms, have been investigated with regard to their cancer preventive and therapeutic effects through epidemiological, in vivo, and in vitro studies. In particular, in vitro studies in cancer cells have evaluated the effects of several B6 vitamers such as pyridoxine, pyridoxal, pyridoxamine, and pyridoxal-5’-phosphate, which is a bioactive form of vitamin B6. However, the anticancer activity and concentration required to influence cancer cells vary among B6 vitamers. In this review, the various in vitro effects of vitamin B6 compounds on cancer cells are presented and discussed.

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What this paper is about

Vitamin B6 compounds, including pyridoxine, pyridoxal, pyridoxamine, and their phosphorylated forms, have been investigated with regard to their cancer preventive and therapeutic effects through epidemiological, in vivo, and in vitro studies. In particular, in vitro studies in cancer cells have evaluated the effects of several B6 vitamers such as pyridoxine, pyridoxal, pyridoxamine, and pyridoxal-5’-phosphate, which is a bioactive form of vitamin B6. However, the anticancer activity and concentration required to influence cancer cells vary among B6 vitamers. In this review, the various in vitro effects of vitamin B6 compounds on cancer cells are presented and discussed.

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Available abstract

Vitamin B6 compounds, including pyridoxine, pyridoxal, pyridoxamine, and their phosphorylated forms, have been investigated with regard to their cancer preventive and therapeutic effects through epidemiological, in vivo, and in vitro studies. In particular, in vitro studies in cancer cells have evaluated the effects of several B6 vitamers such as pyridoxine, pyridoxal, pyridoxamine, and pyridoxal-5’-phosphate, which is a bioactive form of vitamin B6. However, the anticancer activity and concentration required to influence cancer cells vary among B6 vitamers. In this review, the various in vitro effects of vitamin B6 compounds on cancer cells are presented and discussed.

Key concepts: Pyridoxamine, Pyridoxine, Pyridoxal, In vitro, Cancer, Vitamin b, In vivo, Pyridoxal phosphate

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