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Biocatalysis in Organic Synthesis. 9. Highly Enantioselective Kinetic Resolution of Secondary Alcohols Catalyzed by Acylase.1

Juan A. Faraldos, Elisa Arroyo, Bernardo Herradón

Abstract

All articles of this category A new catalytic activity of the enzyme acylase I (AA-I) from Aspergillus species has been found. Although this enzyme had previously been used only in the hydrolysis of N-acylamino acids, we have found that it is a highly efficient catalyst for transesterifications using vinyl esters as acyl donors. The method has been applied to the kinetic resolution of a variety of secondary alcohols. acylase - transesterification - kinetic resolution - acylating agent - solvent effect

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Key concepts: Kinetic resolution, Chemistry, Biocatalysis, Enantioselective synthesis, Catalysis, Hydrolysis, Organic chemistry, Enzyme