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ChemInform Abstract: Syntheses and Antifolate Activity of 5‐Methyl‐5‐deaza Analogues of Aminopterin, Methotrexate, Folic Acid and N10‐Methylfolic Acid.

James R. Piper, George S. Mccaleb, John A. Jr. Montgomery, Roy L. Kisliuk, Yvette Gaumont, Francis M. Sirotnak

Abstract

Abstract Die 5‐Methyl‐5‐desaza‐Ana.‐ loga von Aminopterin (VIIIb), Methotrexat (IXa), Folsäure (XVa) und Methylfolsäure (XVb) werden, ausgehend von den Orthoestern (I) und Malodinitril (II), auf den im Formelschema angegebenen Wegen hergestellt.

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Available abstract

Key concepts: Aminopterin, Folic acid, Methotrexate, Folic Acid Antagonists, Antifolate, Chemistry, Biochemistry, Antimetabolite