2012•Journal of Chemical ResearchRequires access

Facile and Green Method for the Synthesis of 4-Amino-1,2-Dihydrobenzo [4,5]Imidazo[1,2- a ]Pyrimidine-3-Carbonitriles Catalysed by Ammonium Acetate

Lingjun Hu, Zha‐Jun Zhan, Min Lei, Lihong Hu

Abstract

A facile and green method for the synthesis of 4-amino-1,2-dihydrobenzo[4,5]imidazo[1,2- a]pyrimidine-6-carbonitrile derivatives has been developed by one-pot condensation of 2-aminobenzimidazole, aldehydes, and malononitrile catalysed by ammonium acetate in ethanol. The inexpensive and readily available catalyst and easy workup is environmentally friendly.

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Key concepts: Malononitrile, Ammonium acetate, Pyrimidine, Chemistry, Environmentally friendly, Ethanol, Catalysis, Organic chemistry