2012•Journal of Chemical ResearchRequires access

An Efficient One-Pot Synthesis of bis -1-(aroyl)-3-(aryl)thiourea

Razieh Mohebat, Gholam Mohammadian

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Abstract

A three-component and one-pot reaction between 2,6-diaminopyridine or 1,2-diaminobenzene and ammonium thiocyanate with the subsequent addition of an aroyl chloride afforded the bis-1-(aroyl)-3-(aryl)thiourea in excellent yields. It was important to make the thiocyanate derivatives first and then to use those to prepare the thiourea derivatives.

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What this paper is about

A three-component and one-pot reaction between 2,6-diaminopyridine or 1,2-diaminobenzene and ammonium thiocyanate with the subsequent addition of an aroyl chloride afforded the bis-1-(aroyl)-3-(aryl)thiourea in excellent yields. It was important to make the thiocyanate derivatives first and then to use those to prepare the thiourea derivatives.

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OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A three-component and one-pot reaction between 2,6-diaminopyridine or 1,2-diaminobenzene and ammonium thiocyanate with the subsequent addition of an aroyl chloride afforded the bis-1-(aroyl)-3-(aryl)thiourea in excellent yields. It was important to make the thiocyanate derivatives first and then to use those to prepare the thiourea derivatives.

Key concepts: Thiourea, Ammonium thiocyanate, Aryl, Thiocyanate, Chemistry, Chloride, Organic chemistry, Medicinal chemistry

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