An Efficient One-Pot Synthesis of bis -1-(aroyl)-3-(aryl)thiourea
Razieh Mohebat, Gholam Mohammadian
Abstract
Razieh Mohebat, Gholam Mohammadian
Abstract
A three-component and one-pot reaction between 2,6-diaminopyridine or 1,2-diaminobenzene and ammonium thiocyanate with the subsequent addition of an aroyl chloride afforded the bis-1-(aroyl)-3-(aryl)thiourea in excellent yields. It was important to make the thiocyanate derivatives first and then to use those to prepare the thiourea derivatives.
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A three-component and one-pot reaction between 2,6-diaminopyridine or 1,2-diaminobenzene and ammonium thiocyanate with the subsequent addition of an aroyl chloride afforded the bis-1-(aroyl)-3-(aryl)thiourea in excellent yields. It was important to make the thiocyanate derivatives first and then to use those to prepare the thiourea derivatives.
Key concepts: Thiourea, Ammonium thiocyanate, Aryl, Thiocyanate, Chemistry, Chloride, Organic chemistry, Medicinal chemistry