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ChemInform Abstract: ESTERIFICATION OF ISONICOTINIC ACID WITH A CATION EXCHANGER IN THE SYNTHESIS OF ISONICOTINIC ACID HYDRAZIDE

Ya. S. Karpman, L. N. Yakhontov

Abstract

Abstract Erhitzt man Isonicotinsäure (I) mit einem Alkohol, z.B. Butanol, über einem Kationit ( ;z.B. KU‐2‐8) zum Sieden, so entsteht der Isonicotinsäurebutylester, jedoch liegt die Ausbeute nicht über 60%, weil der Stickstoff des Pyridinrings sich an den Kationit bindet, wodurch dieser blockiert wird.

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Key concepts: Isonicotinic acid, Chemistry, Hydrazide, Organic chemistry