Syntheses of putative metabolites of 1,2,3,4‐tetrahydro‐7,12‐dimethylbenz[a]anthracene
Santosh K. Srivastava, Pradeep Kumar Sharma
Abstract
Santosh K. Srivastava, Pradeep Kumar Sharma
Abstract
Abstract Syntheses of (8α,9α,10α,11β)‐trans‐1,2,3,4,8,9,10,11‐octahydro‐7,12‐dimethyl‐8,9‐epoxybenz[a]anthracene‐10,11‐diol (3) and (8α,9α,10β,11α)‐trans‐1,2,3,4,8,9,10,11‐octahydro‐7,12‐dimethyl‐8,9‐epoxybenz[a]anthracene‐10,11‐diol (4), the putative D‐ring metabolites of 1,2,3,4‐tetrahydro‐7,12‐dimethyl‐benz[a]anthracene (1), starting from 1,2,3,4‐tetrahydro‐10‐methoxy‐7,12‐dimethylbenz[a]anthracene (11), are reported.
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Abstract Syntheses of (8α,9α,10α,11β)‐trans‐1,2,3,4,8,9,10,11‐octahydro‐7,12‐dimethyl‐8,9‐epoxybenz[a]anthracene‐10,11‐diol (3) and (8α,9α,10β,11α)‐trans‐1,2,3,4,8,9,10,11‐octahydro‐7,12‐dimethyl‐8,9‐epoxybenz[a]anthracene‐10,11‐diol (4), the putative D‐ring metabolites of 1,2,3,4‐tetrahydro‐7,12‐dimethyl‐benz[a]anthracene (1), starting from 1,2,3,4‐tetrahydro‐10‐methoxy‐7,12‐dimethylbenz[a]anthracene (11), are reported.
Key concepts: Anthracene, 7,12-Dimethylbenz[a]anthracene, Chemistry, Diol, Stereochemistry, Medicinal chemistry, Organic chemistry, Biochemistry