2001•SynthesisRequires access
One-Pot Preparation of Pyranoquinolinones by Ytterbium(III) Trifluoromethanesulfonate-Catalyzed Reactions: Efficient Synthesis of Flindersine, N-Methylflindersine, and Zanthosimuline Natural Products
Yong Rok Lee, Hyuk Il Kweon, Wha Soo Koh, Kyung Rak Min, Youngsoo Kim, Seung Ho Lee
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Abstract
An efficient synthesis of pyranoquinolinones is achieved by ytterbium(III) triflate-catalyzed reaction of 4-hydroxy-2-quinolones with a variety of α,β-unsaturated aldehydes in moderate yields. This new method has been applied to the synthesis of pyranoquinolinone alkaloids.