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2003•Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal ChemistryRequires access

Anticonvulsant activity of semicarbazone derivatives of Mannich bases

S. N. Pandeya, V. Sowmyalakshmi, Siva Sankar Panda, A. Pandeya, James P. Stables

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Abstract

A series of semicarbazones of semicarbazide/p-chlorophenyl semicarbazide and Mannich bases of acetophenone/p-chloro-acetophenone has been synthesized and their anticonvulsant activity screened against MES and scPTZ test. p-Chlorophenyl semicarbazone of N,N-dimethylaminopropiophenone has been found to be the most active in all these tests.

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What this paper is about

A series of semicarbazones of semicarbazide/p-chlorophenyl semicarbazide and Mannich bases of acetophenone/p-chloro-acetophenone has been synthesized and their anticonvulsant activity screened against MES and scPTZ test. p-Chlorophenyl semicarbazone of N,N-dimethylaminopropiophenone has been found to be the most active in all these tests.

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Available abstract

A series of semicarbazones of semicarbazide/p-chlorophenyl semicarbazide and Mannich bases of acetophenone/p-chloro-acetophenone has been synthesized and their anticonvulsant activity screened against MES and scPTZ test. p-Chlorophenyl semicarbazone of N,N-dimethylaminopropiophenone has been found to be the most active in all these tests.

Key concepts: Semicarbazide, Semicarbazone, Acetophenone, Chemistry, Anticonvulsant, Medicinal chemistry, Organic chemistry, Catalysis

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