From Hiring to Firing: Activation of Inhibitory Neurons and Their Recruitment in Behavior

The investigation of GABAergic inhibitory circuits has substantially expanded over the past few years. The development of new tools and technology has allowed investigators to classify many diverse groups of inhibitory neurons by several delineating factors: these include their connectivity motifs, expression of specific molecular markers, receptor diversity, and ultimately their role in brain function. Despite this progress, however, there is still limited understanding of how GABAergic neurons are recruited by their input and how their activity is modulated by behavioral states. This limitation is primarily due to the fact that studies of GABAergic inhibition are mainly geared toward determining how, once activated, inhibitory circuits regulate the activity of excitatory neurons. In this review article, we will outline recent work investigating the anatomical and physiological properties of inputs that activate cortical GABAergic neurons, and discuss how these inhibitory cells are differentially recruited during behavior.