2013•SynthesisRequires access
Facile Synthesis of Hydrazine Derivatives of 5H-Pyrrolo[3,4-b]pyrazine and 1H-Pyrrolo[3,4-b]quinoxaline
Olga V. Hordiyenko, Igor V. Rudenko, Irina A. Zamkova, Oleksandr V. Denisenko, Angelina V. Biitseva, Axelle Arrault, Andrei A. Tolmachev
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Abstract
A convenient and efficient route for the chemoselective synthesis of carbohydrazide, arenesulfonylhydrazide, and thiosemicarbazone derivatives of 5 H -pyrrolo[3,4- b ]pyrazine and 1 H -pyrrolo[3,4- b ]quinoxaline from the corresponding dinitriles and substituted hydrazines was elaborated. The synthesis of starting pyrazine-2,3-dicarbonitrile was sufficiently improved by using concentrated HCl as a catalyst.