1997•Synthetic CommunicationsRequires access
Microwave Enhanced Knoevenagel Condensation of Ethyl Cyanoacetate with Aldehydes
Sang-Yun Kim, Pan‐Suk Kwon, TaeWoo Kwon, Sung‐Kee Chung, Young‐Tae Chang
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Abstract
The reaction rate of Knoevenagel condensation can be dramatically enhanced by irradiating the reaction mixture containing ethyl cyanoacetate, an aldehyde, P2O5, piperidine, and chlorobenzene with a commercial microwave oven. A number of Knoevenagel condensation products were prepared in good yields in very short reaction times (2-15min) under the microwave irradiation.