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2000•Journal of Chemical ResearchRequires access

Heteroaromatization with 4-Hydroxycoumarin Part I: Synthesis of some new Pyranocoumarins and Coumarinopyranopyrimidines

Ahmed M. El‐Agrody, M. S. Abd El‐Latif, A. H. Fakery, Ahmed H. Bedair

Open publisher page 40 citations

Abstract

Considerable interest has been shown in coumarin derivatives, on account of their excellent pharmacological activity 1-3 . In continuation of our work 4-6 , it was of interest to synthesize new coumarin derivatives, which might be biologically active. Thus condensation of 4-hydroxycoumarin 1 with various substituted α-cyanocinnamonitrile 2a-n in ethanolic piperidine afforded pyrano[3,2-c]coumarin derivatives 3a-n (Scheme 1).

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What this paper is about

Considerable interest has been shown in coumarin derivatives, on account of their excellent pharmacological activity 1-3 . In continuation of our work 4-6 , it was of interest to synthesize new coumarin derivatives, which might be biologically active. Thus condensation of 4-hydroxycoumarin 1 with various substituted α-cyanocinnamonitrile 2a-n in ethanolic piperidine afforded pyrano[3,2-c]coumarin derivatives 3a-n (Scheme 1).

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Available abstract

Considerable interest has been shown in coumarin derivatives, on account of their excellent pharmacological activity 1-3 . In continuation of our work 4-6 , it was of interest to synthesize new coumarin derivatives, which might be biologically active. Thus condensation of 4-hydroxycoumarin 1 with various substituted α-cyanocinnamonitrile 2a-n in ethanolic piperidine afforded pyrano[3,2-c]coumarin derivatives 3a-n (Scheme 1).

Key concepts: Coumarin, 4-Hydroxycoumarin, Piperidine, Chemistry, Combinatorial chemistry, Organic chemistry, Catalysis

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Heteroaromatization with 4-Hydroxycoumarin Part I: Synthesis of some new Pyranocoumarins and Coumarinopyranopyrimidines — Research Paper | ScholarLens