2007•Indian Journal of Chemistry Section B-organic Chemistry Including Medicinal ChemistryRequires access
Pyrrolidine catalyzed regioselective and diastereoselective direct aldol reaction in water
Dinesh Mahajan, Swapandeep Singh Chimni
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Abstract
Pyrrolidine catalyzed direct aldol reaction of methyl ketones other than acetone with 4-nitrobenzaldehyde in water affords linear aldol addition product arising from the selective attack of the unsubstituted carbon of the unsymmetrical ketone. The present methodology provides an experimentally simple and green process for regioselective synthesis of β-hydroxyketones in water.