Synthetic studies on optically active and biologically active compounds.

Based on the consideration that biologically active chiral compounds should be prepared in optically active forms which show desired biological activities , the compounds not only exhibiting interesting biological activities but also bearing intriguing structures were selected as synthetic targets and their efficient syntheses were studied by employing optical resolution , asymmetric synthesis and chemical transformation .Thus , efficient syntheses of the anticancer agents such as anthracyclines , nogalamycins, and sesbanimides were accomplished in optically active forms.Syntheses of optically active quinocarcin and fredericamycin A showing pronounced anticancer activities were also studied .A number of efficient synthetic routes to the optically active key intermediates of antibacterial carbapenem antibiotics and antihypertensive peptide-like renin inhibitors were successfully explored.