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A Straightforward Route to Indolizidine and Quinolizidine Analogs as new Potential Antidiabetics

Yves Le Merrer, Christine Gravier‐Pelletier, William Maton

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Abstract

New polyhydroxylated indolizidine and quinolizidine analogs of castanospermine are efficiently obtained by a double reductive amination of enantiopure cyclic ketoaldehydes. As rigidi­fied mimics of disaccharides, these compounds are expected to exhibit significant antidiabetic properties.

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What this paper is about

New polyhydroxylated indolizidine and quinolizidine analogs of castanospermine are efficiently obtained by a double reductive amination of enantiopure cyclic ketoaldehydes. As rigidi­fied mimics of disaccharides, these compounds are expected to exhibit significant antidiabetic properties.

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Available abstract

New polyhydroxylated indolizidine and quinolizidine analogs of castanospermine are efficiently obtained by a double reductive amination of enantiopure cyclic ketoaldehydes. As rigidi­fied mimics of disaccharides, these compounds are expected to exhibit significant antidiabetic properties.

Key concepts: Indolizidine, Quinolizidine, Chemistry, Castanospermine, Enantiopure drug, Swainsonine, Stereochemistry, Amination

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