2019•Bioorganic & Medicinal ChemistryRequires access

Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells

Mutta Kairuki, Qianqian Qiu, Miaobo Pan, Qifei Li, Jiaqi Zhou, Hesham Ghaleb, Wenlong Huang, Hai Qian, Cheng Jiang

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Key concepts: P-glycoprotein, Multiple drug resistance, Chemistry, Doxorubicin, Tetrahydroisoquinoline, Efflux, Pharmacology, Drug resistance

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Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells — Research Paper | ScholarLens