Synthesis of New Tetrakis N-Substituted Tetra-Azamacrocycles

The synthesis of new tetra-kis N- substituted tetra-azamacrocyles was achieved. In the case of tetra amido analogues the best yields were obtained through the use of Schotten - Bauman reaction type in a biphasic system. In the case of tetra-N- ω alkyl carboxylic esters, optimal experimental conditions leading to the desired tetra N-substituted derivatives are described.