1990•ChemInformRequires access
ChemInform Abstract: Analogues of Sialic Acids as Potential Sialidase Inhibitors. Synthesis of 2‐C‐Hydroxymethyl Derivatives of N‐Acetyl‐6‐amino‐2,6‐dideoxy‐neuraminic Acid.
Bruno Bernet, A. R. C. Bulusu Murty, Andrea Vasella
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Abstract
Abstract A variety of title compounds such as (VI) possessing an additional C‐2 hydroxymethyl substituent on the piperidine ring of the aza analogue (VII) of N‐acetylneuraminic acid (Neu5Ac)‐(VIII) are prepared starting from known azidoalkenes such as (I) in order to investigate the influence of the C‐2 substituent on the inhibition of sialidases.