Synthesis And Antiviral Activity Of 2'-Deoxy-2'-Fluoro-L-Arabinofuranosyl 1,2,3-Triazole Derivatives
Süreyya Ölgen, Chung K. Chu
Abstract
Süreyya Ölgen, Chung K. Chu
Abstract
The title compounds were prepared by building up the triazole ring at the anomeric position via the glycosyl azides 5 a,b. The anomeric configurations of these nucleosides were assigned by using 1H, 13C and NOESY NMR spectroscopy. The synthesized nucleosides were evaluated against HIV-1 and HBV
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The title compounds were prepared by building up the triazole ring at the anomeric position via the glycosyl azides 5 a,b. The anomeric configurations of these nucleosides were assigned by using 1H, 13C and NOESY NMR spectroscopy. The synthesized nucleosides were evaluated against HIV-1 and HBV
Key concepts: Anomer, Triazole, Chemistry, Ring (chemistry), Glycosyl, Stereochemistry, 1,2,4-Triazole, Two-dimensional nuclear magnetic resonance spectroscopy