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2019•Acta Endocrinologica (Bucharest)Open access

Streptozotocin-Induced Diabetes Mellitus – a Paradox of High Intrinsic Platelet Reactivity and Low In Vitro Platelet Aggregation

Alina Scridon

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Abstract

CONTEXT: Studies of platelet function in diabetics are inconsistent, some studies reporting higher platelet reactivity, while others showed no change. OBJECTIVE: platelet aggregation in rats with long-lasting (28 weeks) diabetes mellitus. DESIGN: adenosine diphosphate (ADP)-, protease-activated receptor 4 (PAR4) agonist-, and arachidonic acid (AA)-induced platelet aggregation were assessed at the age of 38 weeks. RESULTS: Compared to controls, diabetic rats presented lower platelet count and plateletcrit (both p≤0.001), and higher mean platelet volume (p<0.01). ADP- (p=0.04) and AA-induced (p<0.01) platelet aggregation were lower in diabetic compared with control rats, whereas PAR4 agonist-induced platelet aggregation was similar between the two groups (p=1.00). CONCLUSIONS: thromboembolic events in diabetic rats remains questionable.

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What this paper is about

CONTEXT: Studies of platelet function in diabetics are inconsistent, some studies reporting higher platelet reactivity, while others showed no change. OBJECTIVE: platelet aggregation in rats with long-lasting (28 weeks) diabetes mellitus. DESIGN: adenosine diphosphate (ADP)-, protease-activated receptor 4 (PAR4) agonist-, and arachidonic acid (AA)-induced platelet aggregation were assessed at the age of 38 weeks. RESULTS: Compared to controls, diabetic rats presented lower platelet count and plateletcrit (both p≤0.001), and higher mean platelet volume (p<0.01). ADP- (p=0.04) and AA-induced (p<0.01) platelet aggregation were lower in diabetic compared with control rats, whereas PAR4 agonist-induced platelet aggregation was similar between the two groups (p=1.00). CONCLUSIONS: thromboembolic events in diabetic rats remains questionable.

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Available abstract

CONTEXT: Studies of platelet function in diabetics are inconsistent, some studies reporting higher platelet reactivity, while others showed no change. OBJECTIVE: platelet aggregation in rats with long-lasting (28 weeks) diabetes mellitus. DESIGN: adenosine diphosphate (ADP)-, protease-activated receptor 4 (PAR4) agonist-, and arachidonic acid (AA)-induced platelet aggregation were assessed at the age of 38 weeks. RESULTS: Compared to controls, diabetic rats presented lower platelet count and plateletcrit (both p≤0.001), and higher mean platelet volume (p<0.01). ADP- (p=0.04) and AA-induced (p<0.01) platelet aggregation were lower in diabetic compared with control rats, whereas PAR4 agonist-induced platelet aggregation was similar between the two groups (p=1.00). CONCLUSIONS: thromboembolic events in diabetic rats remains questionable.

Key concepts: Platelet, Diabetes mellitus, Internal medicine, Endocrinology, Streptozotocin, Adenosine diphosphate, Agonist, Arachidonic acid

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Streptozotocin-Induced Diabetes Mellitus – a Paradox of High Intrinsic Platelet Reactivity and Low In Vitro Platelet Aggregation — Research Paper | ScholarLens