Investigating the effects of Matricaria chamomile on prevention of abdominal adhesions among female rats.

Abstract: Introduction: Many abdominopelvic surgeries are performed everyday around the world due to appendicitis, cholecystitis, diagnostic laparatomy, excision of abdominopelvic masses, peritonitis, intestinal occlusions, trauma, visceral rupture and etc. Peritoneal adhesion is one of the most common complications of such surgeries. This complication poses huge costs to patients and society. α- bisabolol that exists in chamomile can play a protective role to prevent these adhesions. Materials and Methods: In this study, 50 female rats were divided into 5 groups: control group, normal saline, chamomile, chamomile plus L- Name, and chamomile plus indometacin. Intravenous ketamine was used to anesthetize the rats. After shaving and disinfecting the abdominal region, multiple scratches were made in the peritoneum and then, the abdomen was closed. After two weeks surgery, a relaparotomy was performed and a sample of the peritoneum was sent to the laboratory for adhesion grading and histopathological examination. The collected data was entered SPSS software for statistical analysis. Results: The findings of this study showed that the rats of the chamomile group showed significantly less adherence, fibrosis, inflammation and vascular proliferation after surgery in comparison to other groups (p⩽0.001). Conclusion: Despite many efforts made to prevent peritoneal adhesions with using different drugs, or various surgical techniques, no pleasant results have been achieved. Using herbal compounds such as chamomile is cheaper, has resulted in fewer complications and has an important effect in preventing abdominal adhesions.