Alteration of Streptokinase-Induced Fibrinolysis Under Clinically Relevant Conditions

Testing streptokinase-induced fibrinolysis in human plasma we obtained the following results: Optimal fibrinolysis takes part at pH-values between 6.8 and 7.25, at NaCl-concentrations between 0.04 and 0.08 g/1, at temperatures between 36° and 42°, and at streptokinase-concentrations between 0.05 and 2 U/ml plasma. Outside of these ranges fibrinolytic activity is reduced. No correlation was found between streptokinase-induced fibrinolysis and hemoglobin concentration, but a strongly positive correlation between fibrinolysis and erythrocyte stromata concentration.