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2019•Clinical Case ReportsOpen access

Brentuximab vedotin as monotherapy for unresectable breast implant‐associated anaplastic large cell lymphoma

Anthony Stack, Isaac Lévy

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Abstract

BI-ALCL is a rare CD30+ T-cell malignancy, which is known to complicate textured breast implants. The CD30-targeting immunoconjugate, brentuximab vedotin, has been suggested for invasive BI-ALCL; however, its efficacy for unresectable BI-ALCL has not been demonstrated. We present a case of unresectable BI-ALCL, which was successfully treated with brentuximab vedotin.

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What this paper is about

BI-ALCL is a rare CD30+ T-cell malignancy, which is known to complicate textured breast implants. The CD30-targeting immunoconjugate, brentuximab vedotin, has been suggested for invasive BI-ALCL; however, its efficacy for unresectable BI-ALCL has not been demonstrated. We present a case of unresectable BI-ALCL, which was successfully treated with brentuximab vedotin.

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OpenAlex reports 15 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

BI-ALCL is a rare CD30+ T-cell malignancy, which is known to complicate textured breast implants. The CD30-targeting immunoconjugate, brentuximab vedotin, has been suggested for invasive BI-ALCL; however, its efficacy for unresectable BI-ALCL has not been demonstrated. We present a case of unresectable BI-ALCL, which was successfully treated with brentuximab vedotin.

Key concepts: Brentuximab vedotin, Anaplastic large-cell lymphoma, Medicine, Trabectedin, Internal medicine, CD30, Oncology, Malignancy

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Brentuximab vedotin as monotherapy for unresectable breast implant‐associated anaplastic large cell lymphoma — Research Paper | ScholarLens