Parents exacerbated fructose intake causes early cardiovascular autonomic dysfunctions in offspring

The aim this study was to evaluate the effects on birth weight and metabolic, hemodynamic and autonomic profiles in offspring of parents submitted to chronic fructose overload. The Fructose genitor group was formed by adult Wistar rats (males and females) that underwent a fructose overload (10%) in drinking water for 60 days. The Control genitor group was formed by adult Wistar rats (males and females) who were only followed for the same period receiving a standard diet. Mating was carried out and the females continued to receive the same diet (fructose or standard) during all gestation and lactation. The offspring were weighed on the day of birth; the day of birth of the offspring was considered the day 0 (zero) of the protocol. After weaning, offspring were divided into group C (descendants of control parents, n = 7) and group F (descendants of fructose parents, n = 7). The groups were evaluated 30 days after weaning. Metabolic parameters were measured with reagent strips. Blood pressure (BP) were recorded directly. Cardiovascular autonomic modulation was evaluated by spectral analysis. Birth weight was lower in F when compared to C group (5.82 ± 0.06 vs. C: 6.42 ± 0.06 g). Regarding metabolic evaluations, the glucose and triglycerides were similar between studied groups. The mean (C: 106 ± 2.7 vs. F: 110 ± 3.4 mmHg), systolic and diastolic BP and the heart rate were similar between the groups studied. However, the F group showed lower cardiac parasympathetic modulation than C group, evidenced by a reduction in cardiac high frequency band (F: 74.40 ± 3.36 vs. C: 88.20 ± 2.21 nu) and higher cardiac sympathetic modulation (F: 25.60 ± 3.36 vs. C: 11.80 ± 2.21). Additionally, the F group showed increase in the sympatho‐vagal balance compared to the C group (0.37 ± 0.06 vs. C: 0.14 ± 0.03). Moreover, higher vascular sympathetic modulation, evidenced by increase of the low frequency band (F: 5.64 ± 1.17 vs. C: 2.25 ± 0.49 mmHg²), was observed in F in relation to C group. In conclusion, offspring of parents submitted to fructose overload present low birth weight and early cardiovascular autonomic dysfunction in adult life. These findings suggest that the inadequate consumption of fructose from the parents may be associated with the onset of cardiovascular disease in offspring in adult life. Support or Funding Information FAPESP (2018/17183‐4); CAPES, CNPq. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .