2017Natural Product CommunicationsOpen access

Cyclopiperettine, A New Amide from Piper nigrum

Jie Ren, Ting Zeng, Zulfıqar Ali, Mei Wang, Ji‐Yeong Bae, Amar G. Chittiboyina, Wei Wang, Shunxiang Li, Ikhlas A. Khan

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Abstract

Cyclopiperettine, a new amide, was isolated from essential oil of Piper nigrum L. together with ten known compounds, including amides, monoterpenoids, and sesquiterpenoids. The structure of cyclopiperettine was established by 1D- and 2D- NMR and GC-MS techniques. Known compounds were identified as α-humulene, β-caryophyllene, caryophyllenol-II, β-elemene, elemol, 1-terpinen-4-ol, nerolidol, pellitorine, piperolein B and piperine. The crude oil and isolated compounds exhibited no antimicrobial activity against seven microbial strains up to 20 μg/mL.

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What this paper is about

Cyclopiperettine, a new amide, was isolated from essential oil of Piper nigrum L. together with ten known compounds, including amides, monoterpenoids, and sesquiterpenoids. The structure of cyclopiperettine was established by 1D- and 2D- NMR and GC-MS techniques. Known compounds were identified as α-humulene, β-caryophyllene, caryophyllenol-II, β-elemene, elemol, 1-terpinen-4-ol, nerolidol, pellitorine, piperolein B and piperine. The crude oil and isolated compounds exhibited no antimicrobial activity against seven microbial strains up to 20 μg/mL.

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Available abstract

Cyclopiperettine, a new amide, was isolated from essential oil of Piper nigrum L. together with ten known compounds, including amides, monoterpenoids, and sesquiterpenoids. The structure of cyclopiperettine was established by 1D- and 2D- NMR and GC-MS techniques. Known compounds were identified as α-humulene, β-caryophyllene, caryophyllenol-II, β-elemene, elemol, 1-terpinen-4-ol, nerolidol, pellitorine, piperolein B and piperine. The crude oil and isolated compounds exhibited no antimicrobial activity against seven microbial strains up to 20 μg/mL.

Key concepts: Piper, Piperine, Nerolidol, Amide, Chemistry, Antimicrobial, Essential oil, Traditional medicine

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