Cyclopiperettine, A New Amide from Piper nigrum
Jie Ren, Ting Zeng, Zulfıqar Ali, Mei Wang, Ji‐Yeong Bae, Amar G. Chittiboyina, Wei Wang, Shunxiang Li, Ikhlas A. Khan
Abstract
Jie Ren, Ting Zeng, Zulfıqar Ali, Mei Wang, Ji‐Yeong Bae, Amar G. Chittiboyina, Wei Wang, Shunxiang Li, Ikhlas A. Khan
Abstract
Cyclopiperettine, a new amide, was isolated from essential oil of Piper nigrum L. together with ten known compounds, including amides, monoterpenoids, and sesquiterpenoids. The structure of cyclopiperettine was established by 1D- and 2D- NMR and GC-MS techniques. Known compounds were identified as α-humulene, β-caryophyllene, caryophyllenol-II, β-elemene, elemol, 1-terpinen-4-ol, nerolidol, pellitorine, piperolein B and piperine. The crude oil and isolated compounds exhibited no antimicrobial activity against seven microbial strains up to 20 μg/mL.
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Cyclopiperettine, a new amide, was isolated from essential oil of Piper nigrum L. together with ten known compounds, including amides, monoterpenoids, and sesquiterpenoids. The structure of cyclopiperettine was established by 1D- and 2D- NMR and GC-MS techniques. Known compounds were identified as α-humulene, β-caryophyllene, caryophyllenol-II, β-elemene, elemol, 1-terpinen-4-ol, nerolidol, pellitorine, piperolein B and piperine. The crude oil and isolated compounds exhibited no antimicrobial activity against seven microbial strains up to 20 μg/mL.
Key concepts: Piper, Piperine, Nerolidol, Amide, Chemistry, Antimicrobial, Essential oil, Traditional medicine