2018•Worldwide Protein Data BankRequires access

Structure of Herceptin Fab without antigen

Ansha Luthra, D.B. Langley, M. Christie, D. Christ

Abstract

We developed a repertoire approach to generate human antibody bispecifics. Using phage display selection of antibody heavy chains in the presence of a competitor light chain and providing a cognate light chain with an affinity handle, we identified mutations that prevent heavy/light chain mispairing. The strategy allows for the selection of human antibody chains that autonomously assemble into bispecifics.

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Available abstract

Key concepts: Immunoglobulin light chain, Phage display, Selection (genetic algorithm), Heavy chain, Antibody, Antibody Repertoire, Computational biology, Repertoire