ScholarLens Back to search
2009•Pakistan Journal of PhysiologyOpen access

SHORT REVIEW OF REPRODUCTIVE PHYSIOLOGY OF MELATONIN

Puja Dullo, Rahul Chaudhary

Open full text 4 citations

Abstract

Epiphysis Cerebri also known as the Pineal gland produces the hormone melatonin. In 1955 Lerner and Takahashi first developed a so-called bioassay for melatonin determination based on a qualification of frog skin blanching Now melatonin is considered a hormone (N-acetyl-5 methoxy tryptamine) produced especially at night in pineal gland. Its secretion is stimulated by dark and inhibited by light, which takes place in the pinealocytes, the cellular unit of the pineal gland. Tryptophan is converted to serotonin and finally converted to melatonin, which is an Indole. Melatonin is metabolized to 6-hydroxyl-mel in the liver and the main metabolite excreted is 6-sulphatoxy-mel and this excretion urinary component is helpful in assessing pineal gland function especially in children

About this research paper

What this paper is about

Epiphysis Cerebri also known as the Pineal gland produces the hormone melatonin. In 1955 Lerner and Takahashi first developed a so-called bioassay for melatonin determination based on a qualification of frog skin blanching Now melatonin is considered a hormone (N-acetyl-5 methoxy tryptamine) produced especially at night in pineal gland. Its secretion is stimulated by dark and inhibited by light, which takes place in the pinealocytes, the cellular unit of the pineal gland. Tryptophan is converted to serotonin and finally converted to melatonin, which is an Indole. Melatonin is metabolized to 6-hydroxyl-mel in the liver and the main metabolite excreted is 6-sulphatoxy-mel and this excretion urinary component is helpful in assessing pineal gland function especially in children

Why it matters

OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Epiphysis Cerebri also known as the Pineal gland produces the hormone melatonin. In 1955 Lerner and Takahashi first developed a so-called bioassay for melatonin determination based on a qualification of frog skin blanching Now melatonin is considered a hormone (N-acetyl-5 methoxy tryptamine) produced especially at night in pineal gland. Its secretion is stimulated by dark and inhibited by light, which takes place in the pinealocytes, the cellular unit of the pineal gland. Tryptophan is converted to serotonin and finally converted to melatonin, which is an Indole. Melatonin is metabolized to 6-hydroxyl-mel in the liver and the main metabolite excreted is 6-sulphatoxy-mel and this excretion urinary component is helpful in assessing pineal gland function especially in children

Key concepts: Melatonin, Pineal gland, Pinealocyte, Tryptamine, Endocrinology, Internal medicine, Metabolite, Serotonin

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
SHORT REVIEW OF REPRODUCTIVE PHYSIOLOGY OF MELATONIN — Research Paper | ScholarLens