ScholarLens Back to search
2019•Neurology GeneticsOpen access

Unraveling the genetic complexity of Alzheimer disease with Mendelian Randomization

Sara Bandrés‐Ciga, Faraz Faghri

Open full text 1 citations

Abstract

Genome-wide association studies (GWASs) have changed the way we conceive human genetics and have led to the discovery of thousands of risk variants involved in disease etiology. However, despite tremendous advances made in understanding the genetic architecture underlying disease, there remains an underinvestigated component of risk, namely phenotypic traits that can predispose or protect individuals to disease. The availability of large amounts of GWAS data affords the opportunity to investigate the relationship between myriad traits.1

Open-access reader

About this research paper

What this paper is about

Genome-wide association studies (GWASs) have changed the way we conceive human genetics and have led to the discovery of thousands of risk variants involved in disease etiology. However, despite tremendous advances made in understanding the genetic architecture underlying disease, there remains an underinvestigated component of risk, namely phenotypic traits that can predispose or protect individuals to disease. The availability of large amounts of GWAS data affords the opportunity to investigate the relationship between myriad traits.1

Why it matters

OpenAlex reports 1 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Genome-wide association studies (GWASs) have changed the way we conceive human genetics and have led to the discovery of thousands of risk variants involved in disease etiology. However, despite tremendous advances made in understanding the genetic architecture underlying disease, there remains an underinvestigated component of risk, namely phenotypic traits that can predispose or protect individuals to disease. The availability of large amounts of GWAS data affords the opportunity to investigate the relationship between myriad traits.1

Key concepts: Mendelian randomization, Disease, Genome-wide association study, Mendelian inheritance, Genetic association, Genetic architecture, Biology, Genetics

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Unraveling the genetic complexity of Alzheimer disease with Mendelian Randomization — Research Paper | ScholarLens