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2018•Universal Journal of Medical ScienceOpen access

Proinflammatory Cytokines IL-2, IL-6 and TNF Alpha as Immunoseralogic Indicators of Chronic Viral Hepatitis B and C in Children

Raba Tatiana

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Abstract

The role of proinflammatory cytokines IL-2, IL-6, and TNF-a in the pathogenesis of chronic hepatitis B and C infection was studied in 49 children ages 3 to 18 years. There has been concluded that high IL-2 and low IL-6 serum levels related to hepatic inflammatory activity did not depend on viremia levels. Slow progression of the disease was associated with an insignificant increase of IL-6 and normal TNF-a serum levels. The study results show the importance of proinflammatory cytokines as diagnostic and prognostic indicators in the pathogenesis of chronic hepatitis B and C in children.

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The role of proinflammatory cytokines IL-2, IL-6, and TNF-a in the pathogenesis of chronic hepatitis B and C infection was studied in 49 children ages 3 to 18 years. There has been concluded that high IL-2 and low IL-6 serum levels related to hepatic inflammatory activity did not depend on viremia levels. Slow progression of the disease was associated with an insignificant increase of IL-6 and normal TNF-a serum levels. The study results show the importance of proinflammatory cytokines as diagnostic and prognostic indicators in the pathogenesis of chronic hepatitis B and C in children.

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Available abstract

The role of proinflammatory cytokines IL-2, IL-6, and TNF-a in the pathogenesis of chronic hepatitis B and C infection was studied in 49 children ages 3 to 18 years. There has been concluded that high IL-2 and low IL-6 serum levels related to hepatic inflammatory activity did not depend on viremia levels. Slow progression of the disease was associated with an insignificant increase of IL-6 and normal TNF-a serum levels. The study results show the importance of proinflammatory cytokines as diagnostic and prognostic indicators in the pathogenesis of chronic hepatitis B and C in children.

Key concepts: Proinflammatory cytokine, Immunology, Tumor necrosis factor alpha, Chronic hepatitis, Medicine, Virology, Inflammation, Virus

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Proinflammatory Cytokines IL-2, IL-6 and TNF Alpha as Immunoseralogic Indicators of Chronic Viral Hepatitis B and C in Children — Research Paper | ScholarLens