2011•European Journal of ImmunologyOpen access
Cover Picture: Eur. J. Immunol. 5/11
Jason Roszik, Zsolt Sebestyén, Coen Govers, Yakir Guri, Árpád Szöőr, Zsuzsanna Pályi‐Krekk, György Vereb, Péter Nagy, János Szöllõsi, Reno Debets
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Abstract
Abstract The cover image of this issue consists of a confocal microscopic FRET image showing immunological synapse formation in Jurkat T cells, and is taken from Roszik et al. (pp. 1288–1297). In this article, the authors characterize TCR‐ζ, a heterodimer of TCR‐α and β chains each coupled to complete human CD3ζ, in gene‐engineered T cells and assess whether this receptor is able to interact with surface molecules and drive correct synapse formation in Jurkat T cells. The authors notably demonstrate that TCR‐ζ is able to induce synapse formation upon antigen recognition, and that synapse formation induced by TCR‐ζ is independent of TCR‐CD3.
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