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Inflammatory Bowel Disease, Genetics of

Charlie W. Lees, Gwo‐Tzer Ho, Jack Satsangi

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Abstract

Abstract Genetic studies of the chronic inflammatory bowel diseases, Crohn disease (CD) and ulcerative colitis (UC), represent a paradigm for complex disease genetics having seen several notable breakthroughs. Indeed, the discovery of NOD2/CARD15 as a CD susceptibility gene in 2001 was the first in a complex genetic disorder. In this review, we detail the genetic epidemiology in inflammatory bowel disease, genome‐wide linkage and association studies, and candidate genes highlighting the insights they have provided into disease pathogenesis and therapeutics.

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What this paper is about

Abstract Genetic studies of the chronic inflammatory bowel diseases, Crohn disease (CD) and ulcerative colitis (UC), represent a paradigm for complex disease genetics having seen several notable breakthroughs. Indeed, the discovery of NOD2/CARD15 as a CD susceptibility gene in 2001 was the first in a complex genetic disorder. In this review, we detail the genetic epidemiology in inflammatory bowel disease, genome‐wide linkage and association studies, and candidate genes highlighting the insights they have provided into disease pathogenesis and therapeutics.

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Available abstract

Abstract Genetic studies of the chronic inflammatory bowel diseases, Crohn disease (CD) and ulcerative colitis (UC), represent a paradigm for complex disease genetics having seen several notable breakthroughs. Indeed, the discovery of NOD2/CARD15 as a CD susceptibility gene in 2001 was the first in a complex genetic disorder. In this review, we detail the genetic epidemiology in inflammatory bowel disease, genome‐wide linkage and association studies, and candidate genes highlighting the insights they have provided into disease pathogenesis and therapeutics.

Key concepts: NOD2, Inflammatory bowel disease, Ulcerative colitis, Disease, Genome-wide association study, Genetics, Candidate gene, Genetic association

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