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2019•Journal of Clinical MicrobiologyOpen access

Performance of a Novel Low-Cost, Instrument-Free Plasma Separation Device for HIV Viral Load Quantification and Determination of Treatment Failure in People Living with HIV in Malaysia: a Diagnostic Accuracy Study

Minh Duc Pham, Berhan A. Haile, Iskandar Azwa, Adeeba Kamarulzaman, Nishaan Raman, Alireza Saeidi, Maria Kahar Bador, Margaret Tan, Jiawei Zhu, Yi Feng, Julian Elliott, Mary L. Garcia, Fan Li, Suzanne M. Crowe, Stanley M. F. Luchters, David A. Anderson

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Abstract

copies/ml (SD, 0.84) between the DBS and plasma. HIV VL measurement using the FDPS outperformed that with the DBS in identifying treatment failure at a threshold of 1,000 copies/ml and compared well with the quantification of VL in plasma. The FDPS can be an attractive alternative to fresh plasma for improving access to HIV VL monitoring among people living with HIV on ART in LMICs.

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copies/ml (SD, 0.84) between the DBS and plasma. HIV VL measurement using the FDPS outperformed that with the DBS in identifying treatment failure at a threshold of 1,000 copies/ml and compared well with the quantification of VL in plasma. The FDPS can be an attractive alternative to fresh plasma for improving access to HIV VL monitoring among people living with HIV on ART in LMICs.

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Available abstract

copies/ml (SD, 0.84) between the DBS and plasma. HIV VL measurement using the FDPS outperformed that with the DBS in identifying treatment failure at a threshold of 1,000 copies/ml and compared well with the quantification of VL in plasma. The FDPS can be an attractive alternative to fresh plasma for improving access to HIV VL monitoring among people living with HIV on ART in LMICs.

Key concepts: Viral load, Human immunodeficiency virus (HIV), Antiretroviral therapy, Medicine, Antiretroviral treatment, Lentivirus, HIV screening, Immunology

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