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2019•Journal of VirologyOpen access

Ceramide Suppresses Influenza A Virus Replication In Vitro

Nadia Soudani, Rouba Hage‐Sleiman, Walid G. Karam, Ghassan S. Dbaibo, Hassan Zaraket

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Abstract

Understanding the effect of sphingolipid metabolism on viral pathogenesis provide important insights into the development of therapeutic strategies against microbial infections. In this study, we demonstrate a critical role of ceramide during influenza A virus infection. We demonstrate that ceramide produced through de novo biosynthesis possess an antiviral role. These observations unlock new opportunities for the development of novel antiviral therapies against influenza.

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What this paper is about

Understanding the effect of sphingolipid metabolism on viral pathogenesis provide important insights into the development of therapeutic strategies against microbial infections. In this study, we demonstrate a critical role of ceramide during influenza A virus infection. We demonstrate that ceramide produced through de novo biosynthesis possess an antiviral role. These observations unlock new opportunities for the development of novel antiviral therapies against influenza.

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OpenAlex reports 51 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Understanding the effect of sphingolipid metabolism on viral pathogenesis provide important insights into the development of therapeutic strategies against microbial infections. In this study, we demonstrate a critical role of ceramide during influenza A virus infection. We demonstrate that ceramide produced through de novo biosynthesis possess an antiviral role. These observations unlock new opportunities for the development of novel antiviral therapies against influenza.

Key concepts: Ceramide, Biology, Viral replication, Sphingolipid, Influenza A virus, Ceramide synthase, Virus, Cell biology

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