2019RePub (Erasmus University Rotterdam)Open access

On the Myelination of GABAergic Interneurons

Jeffrey Stedehouder

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Abstract

Myelination is the insulating ensheathment of axons by oligodendrocytes to increase action potential propagation and provide metabolic support. GABAergic interneurons are a heterogeneous group of predominantly local, inhibitory cells. In schizophrenia, a major debilitating psychiatric disorder, both myelination as well as functioning of GABAergic interneurons have independently been suggested to be impaired. Whether GABAergic interneurons themselves show myelination, remains unknown. Here, we show that GABAergic myelination has been extensive

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Myelination is the insulating ensheathment of axons by oligodendrocytes to increase action potential propagation and provide metabolic support. GABAergic interneurons are a heterogeneous group of predominantly local, inhibitory cells. In schizophrenia, a major debilitating psychiatric disorder, both myelination as well as functioning of GABAergic interneurons have independently been suggested to be impaired. Whether GABAergic interneurons themselves show myelination, remains unknown. Here, we show that GABAergic myelination has been extensive

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Available abstract

Myelination is the insulating ensheathment of axons by oligodendrocytes to increase action potential propagation and provide metabolic support. GABAergic interneurons are a heterogeneous group of predominantly local, inhibitory cells. In schizophrenia, a major debilitating psychiatric disorder, both myelination as well as functioning of GABAergic interneurons have independently been suggested to be impaired. Whether GABAergic interneurons themselves show myelination, remains unknown. Here, we show that GABAergic myelination has been extensive

Key concepts: Interneuron, GABAergic, Neuroscience, Parvalbumin, Biology, Inhibitory postsynaptic potential

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