Experimental Study of the Tissue Repair of Neo-Esophagus After Esophageal Muscularis Resection

Attempts have been made to observe the tissue repair of neo-esophagus after esophageal muscularis resection and to investigate possibility of the regeneration repair of esophageal muscularis resection in neo-esophagus. Sixteen pigs were divided into two groups: group A and group B. Pigs in group A were performed with the partial resection of mere esophageal muscularis propria reserved mucosa muscle layer in a segment of thoracic esophagus. Pigs in group B were performed with nitinol composite artificial esophagus with polyester sewing rings replacement a segment of thoracic esophagus resection. Pigs in the two groups were performed with euthanasia at the following times: 2, 4, 6, and 12 months for postmortem analysis, which demonstrated the absence of esophageal muscularis regeneration in the specimens that were sampled from different time points. Reserved mucosa muscle layer did not show hyperplasia to repair coloboma of esophageal muscularis propria deletion in group A. These results suggest that after esophageal muscularis resection, including mucosa muscle layer or esophageal muscularis propria, the coloboma of esophageal muscularis was repaired with connective tissue filling quickly. It would be very difficult for the regeneration repair of esophageal muscularis in neo-esophageal tissue structure after esophageal muscularis resection.