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2019•NeurologyRequires access

Serum neurofilament light and prediction of multiple sclerosis in clinically isolated syndrome

Henrik Zetterberg, Anders Svenningsson

Open publisher page 6 citations

Abstract

Clinically isolated syndrome (CIS) refers to a first episode of multiple sclerosis (MS)–like neurologic symptoms that lasts at least 24 hours followed by complete or partial recovery. Individuals who experience CIS may or may not go on to develop MS. The most notable risk factors for MS during follow-up are MRI lesions and CSF oligoclonal bands.1 More recently, CSF neurofilament light (NfL) concentration, a general marker of axonal injury, has been proposed as predictive of future MS in CIS.2

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What this paper is about

Clinically isolated syndrome (CIS) refers to a first episode of multiple sclerosis (MS)–like neurologic symptoms that lasts at least 24 hours followed by complete or partial recovery. Individuals who experience CIS may or may not go on to develop MS. The most notable risk factors for MS during follow-up are MRI lesions and CSF oligoclonal bands.1 More recently, CSF neurofilament light (NfL) concentration, a general marker of axonal injury, has been proposed as predictive of future MS in CIS.2

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OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Clinically isolated syndrome (CIS) refers to a first episode of multiple sclerosis (MS)–like neurologic symptoms that lasts at least 24 hours followed by complete or partial recovery. Individuals who experience CIS may or may not go on to develop MS. The most notable risk factors for MS during follow-up are MRI lesions and CSF oligoclonal bands.1 More recently, CSF neurofilament light (NfL) concentration, a general marker of axonal injury, has been proposed as predictive of future MS in CIS.2

Key concepts: Multiple sclerosis, Clinically isolated syndrome, Medicine, Neurofilament, McDonald criteria, Pathology, Internal medicine, Immunology

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