2019•Proceedings of the National Academy of Sciences of Belarus Medical seriesOpen access

Application of basophil activation and degranulation markers for diagnosis of pollen allergy

I.U. Ramanava, Andrei Hancharou, N. I. Dudarava

Abstract

There are several basophil activation and degranulation markers for basophil activation test discovered in recent years. However, only CD63 and CD203c are actively used. The activation and degranulation markers (CD11b, CD13, CD63, CD69, CD107a, CD164, CD203c and CD300a) were characterized from the point of view of the possibility to use for BAT and their clinical efficiency. It has been shown that the degranulation marker CD107a and the activation marker CD11b have high sensitivity and specificity and can be used to diagnose hypersensitivity to pollen allergens.

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Key concepts: Degranulation, Basophil activation, CD63, Immunology, Allergy, Chemistry, Biology, Immunoglobulin E