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2019•PubMedOpen access

Expression of CD34 and CD31 in Central and Peripheral Giant Cell Granulomas.

Donia Sadri, Fatemeh Shahsavari, Maliheh Hezarkhani, Maryam Shafizadeh

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Abstract

STATEMENT OF THE PROBLEM: There are some differences between clinical features of central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (CGCGs) despite their same microscopic features. The possible role of angiogenesis in this issue is still a matter of debate. PURPOSE: The aim of the present study was to compare microvessel density (MVD) between CGCGs and PGCGs of the oral cavity using CD31 and CD34. MATERIALS AND METHOD: < 0.05 was considered significant. RESULTS: < 0.2). CONCLUSION: The combined evaluation of old- and newly-formed vessels by pan-endothelial cell markers showed differences between CGCGs and PGCGs, supporting the possible vascular-proliferative nature of the former. Whether this difference has a part in their diverse biologic behaviors and the role which pre-existent vessels play in comparison to neo-formed vasculature, requires further investigation.

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What this paper is about

STATEMENT OF THE PROBLEM: There are some differences between clinical features of central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (CGCGs) despite their same microscopic features. The possible role of angiogenesis in this issue is still a matter of debate. PURPOSE: The aim of the present study was to compare microvessel density (MVD) between CGCGs and PGCGs of the oral cavity using CD31 and CD34. MATERIALS AND METHOD: < 0.05 was considered significant. RESULTS: < 0.2). CONCLUSION: The combined evaluation of old- and newly-formed vessels by pan-endothelial cell markers showed differences between CGCGs and PGCGs, supporting the possible vascular-proliferative nature of the former. Whether this difference has a part in their diverse biologic behaviors and the role which pre-existent vessels play in comparison to neo-formed vasculature, requires further investigation.

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Available abstract

STATEMENT OF THE PROBLEM: There are some differences between clinical features of central giant cell granulomas (CGCGs) and peripheral giant cell granulomas (CGCGs) despite their same microscopic features. The possible role of angiogenesis in this issue is still a matter of debate. PURPOSE: The aim of the present study was to compare microvessel density (MVD) between CGCGs and PGCGs of the oral cavity using CD31 and CD34. MATERIALS AND METHOD: < 0.05 was considered significant. RESULTS: < 0.2). CONCLUSION: The combined evaluation of old- and newly-formed vessels by pan-endothelial cell markers showed differences between CGCGs and PGCGs, supporting the possible vascular-proliferative nature of the former. Whether this difference has a part in their diverse biologic behaviors and the role which pre-existent vessels play in comparison to neo-formed vasculature, requires further investigation.

Key concepts: CD31, CD34, Immunohistochemistry, Angiogenesis, Pathology, Significant difference, Endothelial stem cell, Monoclonal antibody

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Expression of CD34 and CD31 in Central and Peripheral Giant Cell Granulomas. — Research Paper | ScholarLens