The correlation between ischemic lesions and tuberculoma incidence on head CT-Scan and clinical prognosis in tuberculous meningitis patients: A study at Hasan Sadikin Central General Hospital Bandung 2018

Background: Central nervous system (CNS) TB disease occurs only in 2-5% of all tuberculosis patients but has high mortality rate up to 30% and often causes residual symptoms of neurological deficits, only 18% of the patient can return to normal neurological function. Computed Tomography Scan (CT scan) is the initial modality for detecting unique neuroradiological abnormalities in patients with tuberculous meningitis such as ischemic lesions and tuberculoma. Ischemic lesions and tuberculoma are associated with increased neurological complications in patients with tuberculosis and affect the clinical prognosis of tuberculous meningitis patients that can be assessed using Modified Rankin Score (MRS). Objective: To review the correlation between ischemic lesion and tuberculoma on head CT-scan and clinical prognosis of tuberculous meningitis patient. Methods: This study was an observational analytic study with a cross-sectional design. Sampling was done by consecutive admissions sampling in January 2015 to September 2016. The data were analyzed statistically using Chi-Square test. Results: There were 22 subjects. The highest incidence is severe clinical prognosis, being highest found in 59.1% (13 patients). The result of the statistical test using Chi-Square test at 95% confidence degree shows that there is a statistically significant correlation between ischemic lesion and tuberculoma incidence on CT head examination and clinical prognosis of tuberculous meningitis patient Hasan Sadikin Central General Hospital Bandung (value p≤0.05). Conclusion: There is a significant correlation between ischemic lesion and tuberculoma incidence on CT head scan and clinical prognosis of tuberculous meningitis patient at Hasan Sadikin Central General Hospital Bandung with p-value = 0.032 (value p≤0.05).