Correlations of Leptin, Adiponectin and Leptin/Adiponectin Ratio with Metabolic Disorders in the Childhood Obesity

Purpose: To investigate the correlation of the serum leptin, adiponectin, and leptin/adiponectin ratio with metabolic disorders in the childhood obesity.Methods: Fifty children (25 obese and 25 non-obese) were recruited in the pediatric outpatient clinic of Chosun University Hospital from January 1st to June 30th 2005.Adiponectin, leptin, anthropometric parameters, glucose, LDL-cholesterol, HDL-cholesterol, total cholesterol, triglyceride, and insulin levels were measured.The correlations of leptin and adiponectin levels with anthropometric parameters, glucose, insulin and lipids were analyzed by Pearson's correlation coefficients.Results: Insulin and leptin levels of the obese group were significantly higher than those of the non-obese group (p＜0.05,p＜0.001 respectively).HDL-cholesterol and adiponectin levels of the obese group were significantly lower than those of the non-obese group (p＜0.005,p＜0.05 respectively).In the obese group, leptin level was positively correlated with BMI and the percentage of body fat, but negatively correlated with adiponectin level.Moreover, adiponectin level of the obese group was negatively correlated with BMI and the percentage of body fat, but positively correlated with leptin level.In the non-obese group, only insulin level was positively correlated with adiponectin.In the obese group, leptin/adiponectin ratio was positively correlated with the percentage of body fat and leptin level.Also, leptin/adiponectin ratio was positively correlated with BMI and the percentage of body fat in the non-obese group.Conclusion: Leptin, adiponectin, and leptin/adiponectin ratio did not appear to have a major role linking various metabolic disorders in the childhood obesity, even though they were strongly associated with obesity indices.Also, leptin/adiponectin ratio was associated with obesity indices even in non-obese children.(