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2018•Royal Society of Chemistry eBooksRequires access

Production of H2S – The l-cysteine/CSE-CBS-MST/H2S System

Yi Zhun Zhu

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Abstract

Hydrogen sulfide (H2S), a bioactive gasotransmitter, is produced endogenously primarily by three enzymes, cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (MST). This chapter comprehensively reviews the characteristics, mechanisms, and potential regulation of H2S generation by the CSE/CBS/MST system. The production of polysulfide, the predominant form of H2S storage in vivo, is also discussed. In addition, exogenous H2S donors designed for mammalian cells are summarized and classified.

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What this paper is about

Hydrogen sulfide (H2S), a bioactive gasotransmitter, is produced endogenously primarily by three enzymes, cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (MST). This chapter comprehensively reviews the characteristics, mechanisms, and potential regulation of H2S generation by the CSE/CBS/MST system. The production of polysulfide, the predominant form of H2S storage in vivo, is also discussed. In addition, exogenous H2S donors designed for mammalian cells are summarized and classified.

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Available abstract

Hydrogen sulfide (H2S), a bioactive gasotransmitter, is produced endogenously primarily by three enzymes, cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (MST). This chapter comprehensively reviews the characteristics, mechanisms, and potential regulation of H2S generation by the CSE/CBS/MST system. The production of polysulfide, the predominant form of H2S storage in vivo, is also discussed. In addition, exogenous H2S donors designed for mammalian cells are summarized and classified.

Key concepts: Sulfurtransferase, Cystathionine beta synthase, Cystathionine gamma-lyase, Cysteine, Hydrogen sulfide, Polysulfide, Chemistry, Hydrogen sulphide

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