Studies on serum soluble endoglin: An indicator for preeclampsia

Introduction: To study the concentration of serum soluble endoglin during second trimester pregnancy and monitor for the development of preeclampsia. Materials and Methods: Seventy-five healthy singleton pregnant women in second trimester was evaluated in this study. ELISA technique was used for measuring the concentration of Serum soluble endoglin. Patients with increased level of serum endoglin were monitored for signs and symptoms of preeclampsia. Result: Thirty five pregnant women developed preeclampsia among 75 pregnant women. The mean value for sENG in cases was 8.7 ± 1.4 and control 5.9 ± 0.6. The normal value of serum sENG varies from 2.54 to 7.06 ng/ml. Hence, it is higher than the normal limit in cases. Conclusions: The concentration of sENG was studied and women were monitored for development of preeclampsia. The present study showed that women with increased serum soluble endoglin levels developed preeclampsia later. Hence, it is suggested that soluble endoglin will be useful in predicting pre eclampsia. Keywords: Endoglin, Preeclampsia, ELISA, sENG.