2018•Current Organic ChemistryRequires access

Hypervalent Iodine-Mediated Synthesis of Spiroheterocycles via Oxidative Cyclization

Linlin Xing, Yong Zhang, Yunfei Du

Abstract

Hypervalent iodine reagents have been widely used in the construction of many important building blocks and privileged scaffolds of bioactive natural products. This review article aims to briefly discuss strategies that have used hypervalent iodine reagents as oxidants to synthesize spiroheterocyclic compounds and to stimulate further study for novel syntheses of spiroheterocyclic core structures using hypervalent iodine reagents under metal-free conditions.

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Available abstract

Key concepts: Hypervalent molecule, Chemistry, Iodine, Reagent, Combinatorial chemistry, Iodine compounds, Organic chemistry