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Synthesis and Structural Studies of O-vanillin Indomethacin Hydrazone and P-vanillin Indomethacin Hydrazone

Lamia Madwar

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Abstract

Three steps of two novel ligands of Indomethacin hydrazide based Schiff bases ligands were synthesized. For our targeted ligands, first we synthesized Indomethacin Ethyl Ester (RCOOC 2 H 5 ), This ester was further reacted with hydrazine hydrate to produce Indomethacin acid hydrazide (RCONHNH 2 ). Finally, this hydrazide condensed with o -Vanillin and p -Vanillin to get targeted compounds. Structure confirmation was characterized based on IR, 1 H-NMR and 13 C-NMR spectroscopy. Keywords: NSIADs, Indomethacin, o -Vanillin, p- Vanillin, acid hydrazide, Hydrazone, transition metal complexes, Hydrazide Base Schiff Bases.

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Three steps of two novel ligands of Indomethacin hydrazide based Schiff bases ligands were synthesized. For our targeted ligands, first we synthesized Indomethacin Ethyl Ester (RCOOC 2 H 5 ), This ester was further reacted with hydrazine hydrate to produce Indomethacin acid hydrazide (RCONHNH 2 ). Finally, this hydrazide condensed with o -Vanillin and p -Vanillin to get targeted compounds. Structure confirmation was characterized based on IR, 1 H-NMR and 13 C-NMR spectroscopy. Keywords: NSIADs, Indomethacin, o -Vanillin, p- Vanillin, acid hydrazide, Hydrazone, transition metal complexes, Hydrazide Base Schiff Bases.

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Available abstract

Three steps of two novel ligands of Indomethacin hydrazide based Schiff bases ligands were synthesized. For our targeted ligands, first we synthesized Indomethacin Ethyl Ester (RCOOC 2 H 5 ), This ester was further reacted with hydrazine hydrate to produce Indomethacin acid hydrazide (RCONHNH 2 ). Finally, this hydrazide condensed with o -Vanillin and p -Vanillin to get targeted compounds. Structure confirmation was characterized based on IR, 1 H-NMR and 13 C-NMR spectroscopy. Keywords: NSIADs, Indomethacin, o -Vanillin, p- Vanillin, acid hydrazide, Hydrazone, transition metal complexes, Hydrazide Base Schiff Bases.

Key concepts: Hydrazide, Vanillin, Hydrazone, Chemistry, Hydrazine (antidepressant), Schiff base, Proton NMR, Hydrate

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Synthesis and Structural Studies of O-vanillin Indomethacin Hydrazone and P-vanillin Indomethacin Hydrazone — Research Paper | ScholarLens